The FDA recently approved lifitegrast, a new eye drop for treating signs and symptoms of dry eye in adult patients. Kelly Nichols, OD, PhD, a dry eye expert and dean of the UAB School of Optometry, conducted research studies for the parent drug company to explore the efficacy and safety of lifitegrast in treating this eye condition that affects more than 16 million adults in the United States.
Inflammation associated with dry eye may eventually lead to damage to the surface of the eye.
"Dry eye is a common complaint to eye care professionals, with millions of U.S. adults experiencing the symptoms of this often chronic disease," Nichols said. "It is critical for eye care professionals to have a dialogue with patients who report symptoms because dry eye can be a progressive ocular surface disease."
The twice-daily eye drop solution of five percent lifitegrast ophthalmic solution is the only prescription eye drop indicated for the treatment of both signs and symptoms of dry eye, and it is the first new dry eye prescription drop approved in the last 13 years.
Nichols and a team of researchers studied 1,181 patients, of whom 1,067 received lifitegrast in four placebo-controlled 12-week trials. Signs and symptoms were assessed at baseline and at weeks two, six and 12.
In all four studies, eye dryness was significantly reduced, with two of the studies showing improvements at week two. Results from inferior corneal staining tests -- used by physicians to detect abrasions on the cornea -- showed improvement in three of the four studies.