UAB Developing New Peptide to Combat Familial Hypercholesterolemia


 
G.M. Anantharamaiah, PhD

Researchers at UAB are testing a new peptide that they hope will lead to better treatment options for familial hypercholesterolemia (FH).

FH is a genetic condition that results from the body's inability to clear low-density lipoprotein (LDL), or bad cholesterol, from the blood. This results in startlingly high cholesterol levels. There are two forms of FH: heterozygous FH (HeFH) and homozygous (HoFH) which is the most serious type of FH. If untreated, HoFH often causes heart disease in the early teen years and sometimes even in early childhood.

Professors in the UAB Department of Medicine, G.M. Anantharamaiah, PhD and C. Roger White, PhD are working on the second version of a peptide licensed by Lipimetix, Inc., a biopharmaceutical company. The peptide, called AEM-28-14, has the potential to treat patients suffering from HoFH in a new way instead of the usual treatment of plasma/LDL apheresis.


C. Roger White, PhD

AEM-28-14 inserts into cholesterol-rich lipoproteins and directs them to the receptors on the liver. The lipoproteins are then internalized and degraded through existing pathways, dramatically decreasing blood cholesterol levels for a longer period of time -- nearly two months, compared to plasma/LDL apheresis, which has to be administered every two weeks.

"Current treatments rely on increasing the excretion of LDL via the LDL receptor pathway," Anantharamaiah said. "In FH patients, since LDL receptor is defective, LDL cannot be cleared via this pathway."

Anantharamaiah says the newly developed peptide AEM-28-14 bypasses LDL receptor pathways and has been demonstrated to clear large amounts of LDL in relevant animal models. He believes this may be the most powerful lipid reduction agent yet discovered.

An ideal LDL cholesterol level is typically 130 mg/dL. Adults with FH generally have LDL cholesterol levels of 190 mg/dL and above, and HoFH patients not using medication can have LDL levels between 500 and 1,000 mg/dL which leads to a much greater risk of heart attack or stroke.

According to The FH Foundation, it is now believed that one in 250 people (or 1.3 million people in the United States) have HeFH and one in 160,000 have HoFH.

FH is responsible for 20 percent of all heart attacks in people 45 and younger. If untreated, 50 percent of men with FH will have a heart attack by age 50, and 30 percent of women will have a heart attack by age 60.


Disease Pankaj Arora, MD

UAB Assistant Professor in the Division of Cardiovascular Disease Pankaj Arora, MD says it is imperative to get tested for FH if there is a prior family history of the disorder.

Arora says educating patients about the physical signs of FH can help.

"Education about physical signs such as swollen tendons on the back of the heel, yellow deposits in the skin around the eyes and white deposit of cholesterol around the colored part of the eyes can help to increase awareness," Arora said.

There are only 58 plasma/LDL apheresis centers across the United States, significantly limiting patient access. The scientists hope that this new peptide will lead to better treatment options, which will in turn, lead to more treatment centers for patients to gain access.

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